Pterocarpans and a novel flavanone from harpalyce brasiliana roots
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منابع مشابه
Pterocarpans and a Novel Flavanone from Harpalyce brasiliana Roots
A nova “(-)-7,8,3’,4’-tri-hidróxi-8-(3’’,7’’-dimetil-octa-2’’,6’’-dienoil)-flavanona foi isolada a partir do extrato etanólico das raízes de Harpalyce brasiliana, juntamente com os pterocarpanos conhecidos (-)-2-geranil-3-hidróxi-8,9-metilenodioxipterocarpano, harpalicina, medicarpina, maackiaina e as cabenegrinas A-I e A-II. Os metabólitos isolados foram caracterizados com base nos seus dados ...
متن کاملBioassay-guided fractionation of pterocarpans from roots of Harpalyce brasiliana Benth.
Pterocarpans, a special kind of isoflavonoids possessing two contiguous benzofuran and benzopyran rings, have been reported as possessing several biological activities. In order to isolate and identify the active principles possibly responsible for the stronger activity of the EtOH extract from roots of Harpalyce brasiliana on the antimitotic assay using sea urchin egg development, a bioassay-g...
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Six compounds were isolated from Derris laxiflora Benth., including two new pterocarpans, 7,6'-dihydroxy-3'-methoxypterocarpan (1) and derrispisatin (2), as well as four known ones, lespedezol D, (3), secundiflorol 1 (4), 6a-hydroxymaackiain (5) and pisatin (6). The structures of these compounds were determined by analysis of their spectroscopic data.
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Pterocarpans (1-3) and flavanones (4-10) were isolated from Sophora flavescens and screened for their ability to inhibit neuraminidase (an enzyme crucial in the proliferation of the influenza virus). The majority of inhibitors were shown to have IC(50) values of 20 microM or below. Interestingly, pterocarpan 1 emerged as the best inhibitor with an IC(50) of 1.4 microM. We were thus able to prov...
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ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2009
ISSN: 0103-5053
DOI: 10.1590/s0103-50532009000500019